If needed, 2nd dose reduction of copegus is by an additional 200 mg day.
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Serious adverse events include neuropsychiatric disorderssuicidal ideation and suicide attemptserious and severe bacterial infectionsbone marrow toxicitycytopenia and rarelyaplastic anemiacardiovascular disordershypertensionarrhythmias and myocardial infarctionhypersensitivityincluding anaphylaxisendocrine disordersincluding thyroid disorders and diabetes mellitusautoimmune disordersincluding psoriasis and lupuspulmonary disordersdyspneapneumoniabrochiolitis obliteransinterstitial pneumonitis and sarcoidosiscolitisulcerative and hemorrhagic/ischemiccolitispancreatitisand opthalmologic disordersdecrease or loss of visionretinopathy including macular edema and retinal thrombosis/hemorrhagesoptic neuritis and papilledema
Ribavirin is not effective when used alone to treat hepatitis CIt must be used together with an interferon alfa productsuch as Peg-Intron or Intron Ato treat chronic hepatitis C.
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